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Ivan D Horak Selected Research

Therapeutics

1/2022Paediatric Strategy Forum for medicinal product development of chimeric antigen receptor T-cells in children and adolescents with cancer: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.
1/2020Simultaneous targeting of HER family pro-survival signaling with Pan-HER antibody mixture is highly effective in TNBC: a preclinical trial with PDXs.
1/2019CD4+ and CD8a+ PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models.
4/2018Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial.
1/2018Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.
12/2017Simultaneous Targeting of Two Distinct Epitopes on MET Effectively Inhibits MET- and HGF-Driven Tumor Growth by Multiple Mechanisms.
11/2016Pan-HER-An antibody mixture targeting EGFR, HER2 and HER3 abrogates preformed and ligand-induced EGFR homo- and heterodimers.
10/2013Sym004, a novel EGFR antibody mixture, can overcome acquired resistance to cetuximab.
4/2013Downregulation of HER3 by a novel antisense oligonucleotide, EZN-3920, improves the antitumor activity of EGFR and HER2 tyrosine kinase inhibitors in animal models.
12/2011Reduced expression of the androgen receptor by third generation of antisense shows antitumor activity in models of prostate cancer.
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Ivan D Horak Research Topics

Disease

39Neoplasms (Cancer)
01/2022 - 01/2004
8Colorectal Neoplasms (Colorectal Cancer)
01/2020 - 09/2005
5Non-Hodgkin Lymphoma (Lymphosarcoma)
10/2009 - 04/2004
3Breast Neoplasms (Breast Cancer)
03/2015 - 03/2004
3Hypoxia (Hypoxemia)
09/2011 - 11/2008
3Carcinoma (Carcinomatosis)
06/2011 - 04/2005
3Neoplasm Metastasis (Metastasis)
11/2008 - 04/2005
3Lymphoma (Lymphomas)
12/2005 - 12/2003
3Colonic Neoplasms (Colon Cancer)
11/2005 - 04/2005
2Neuroblastoma
01/2022 - 10/2010
2Glioma (Gliomas)
01/2022 - 09/2011
2Residual Neoplasm
01/2020 - 04/2005
2Glioblastoma (Glioblastoma Multiforme)
07/2018 - 11/2008
2Stomach Neoplasms (Stomach Cancer)
01/2018 - 01/2018
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2016 - 10/2013
2B-Cell Lymphoma (Lymphoma, B Cell)
08/2005 - 12/2003
2Multiple Myeloma
07/2005 - 12/2004
1Hodgkin Disease (Hodgkin's Disease)
01/2022
1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
01/2022
1Head and Neck Neoplasms (Head and Neck Cancer)
01/2021
1Triple Negative Breast Neoplasms
01/2020
1Squamous Cell Carcinoma of Head and Neck
01/2016
1Prostatic Neoplasms (Prostate Cancer)
12/2011
1Necrosis
10/2010

Drug/Important Bio-Agent (IBA)

9AntibodiesIBA
01/2022 - 04/2005
9ErbB Receptors (EGF Receptor)IBA
01/2020 - 06/2011
9Proteins (Proteins, Gene)FDA Link
01/2020 - 01/2004
9Monoclonal AntibodiesIBA
04/2018 - 03/2004
7Pharmaceutical PreparationsIBA
01/2018 - 12/2003
5LigandsIBA
01/2020 - 12/2011
5Irinotecan (Camptosar)FDA LinkGeneric
09/2011 - 04/2005
5Carcinoembryonic AntigenIBA
11/2005 - 04/2005
4Cetuximab (Erbitux)FDA Link
01/2021 - 10/2013
4futuximabIBA
07/2018 - 10/2013
4Messenger RNA (mRNA)IBA
11/2017 - 11/2008
4EZN-2208IBA
09/2011 - 03/2008
4Immunoglobulin G (IgG)IBA
12/2005 - 04/2005
3Immunoconjugates (Immunoconjugate)IBA
01/2022 - 07/2005
3LuciferasesIBA
12/2011 - 10/2010
3HaptensIBA
11/2005 - 10/2005
3Radioisotopes (Radionuclides)IBA
10/2005 - 04/2005
3Rituximab (Mabthera)FDA Link
08/2005 - 04/2004
3AntigensIBA
04/2005 - 04/2004
2RNA (Ribonucleic Acid)IBA
01/2020 - 11/2008
2EpitopesIBA
12/2017 - 10/2013
2Trastuzumab (Herceptin)FDA Link
11/2017 - 03/2015
2Neutralizing AntibodiesIBA
11/2017 - 04/2013
2Tyrosine Kinase InhibitorsIBA
04/2013 - 06/2011
2Phosphotransferases (Kinase)IBA
04/2013 - 06/2011
2Lapatinib (GW572016)FDA Link
04/2013 - 06/2011
2Transcription Factors (Transcription Factor)IBA
12/2011 - 11/2008
2Antisense OligonucleotidesIBA
12/2011 - 02/2010
2Topoisomerase I InhibitorsIBA
09/2011 - 10/2010
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2011 - 10/2010
2Doxorubicin (Adriamycin)FDA LinkGeneric
10/2010 - 07/2005
2ProdrugsIBA
10/2010 - 04/2008
2Immunotoxins (Immunotoxin)IBA
12/2005 - 05/2005
2Peptides (Polypeptides)IBA
11/2005 - 11/2005
2epratuzumabIBA
08/2005 - 04/2004
2Complement System Proteins (Complement)IBA
04/2005 - 04/2004
2IodineIBA
04/2005 - 03/2004
1T-Cell Antigen Receptors (T-Cell Receptor)IBA
01/2022
1Chimeric Antigen ReceptorsIBA
01/2022
1Insulin-Like PeptidesIBA
01/2021
1BuffersIBA
01/2020
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
01/2020
1human ERBB2 proteinIBA
01/2020
1Immune Checkpoint InhibitorsIBA
01/2019
1epidermal growth factor receptor VIIIIBA
07/2018
1Circulating Tumor DNAIBA
04/2018
1emibetuzumabIBA
01/2018
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
01/2018
1Neuregulin-1 (Neuregulin 1)IBA
11/2017
1Panitumumab (Vectibix)FDA Link
06/2015
1pertuzumabIBA
03/2015
1Caspase 3 (Caspase-3)IBA
10/2013
1Gefitinib (Iressa)FDA Link
04/2013
15'-ACCaagtttcttcAGC-3'IBA
12/2011
1enzalutamideIBA
12/2011
1AndrogensIBA
12/2011
1Androgen Receptors (Androgen Receptor)IBA
12/2011
1abirateroneIBA
12/2011
1Testosterone (Sustanon)FDA Link
12/2011
1matrigelIBA
09/2011
1Matrix Metalloproteinases (MMPs)IBA
10/2010
1Histones (Histone)IBA
10/2010
1Therapeutic UsesIBA
10/2010
1Vincristine (Oncovin)FDA LinkGeneric
10/2010
1Cisplatin (Platino)FDA LinkGeneric
10/2010
1DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
10/2010
1Topotecan (Hycamtin)FDA LinkGeneric
10/2010
1FenretinideIBA
10/2010
1SurvivinIBA
02/2010
1EZN 3042IBA
02/2010

Therapy/Procedure

20Therapeutics
01/2022 - 03/2004
5Radioimmunotherapy
11/2005 - 03/2004
3Aftercare (After-Treatment)
01/2020 - 09/2011
2Immunotherapy
01/2022 - 01/2019
2Drug Therapy (Chemotherapy)
08/2005 - 04/2005
1Castration
12/2011